2015年5月17日 星期日

[論文發表] A Clinical Study of Integrating Acupuncture and Western Medicine in Treating Patients with Parkinson's Disease (SCI)




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 http://www.worldscientific.com/doi/abs/10.1142/S0192415X15500263?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

A Clinical Study of Integrating Acupuncture and Western Medicine in Treating Patients with Parkinson's Disease
Fang-Pey Chen

  • Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
  • National Yang-Ming University School of Medicine, Taipei, Taiwan
  • Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
  • Ching-Mao Chang

  • Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
  • Jing-Huei Shiu

  • Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
  • Jen-Hwey Chiu

  • Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
  • Ta-Peng Wu

  • Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
  • Jen-Lin Yang

  • Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
  • Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
  • Yen-Ying Kung

  • Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
  • National Yang-Ming University School of Medicine, Taipei, Taiwan
  • Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
  • Fun-Jou Chen

  • School of Chinese Medicine, China Medical University, Taichung, Taiwan
  • Chang-Ming Chern

  • Correspondence to: Associate Prof. Chang-Ming Chern, Department of Family Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Beitou District, Taipei 112, Taiwan, Tel: (+886) 2-2875-7578, Fax: (+886) 2-2875-7579.
  • Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan
  • Shinn-Jang Hwang

  • Correspondence to: Prof. Shinn-Jang Hwang, Department of Family Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Beitou District, Taipei 112, Taiwan, ROC. Tel: (+886) 2-2875-7460, Fax: (+886) 2-2873-7901.
  • Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
  • National Yang-Ming University School of Medicine, Taipei, Taiwan
  • Published: 5 May 2015

    Complementary therapy with acupuncture for Parkinson's disease (PD) has been studied for quite a long time, but the effectiveness of the treatment still remains unclear. The aim of this study is to evaluate the integrated effects of acupuncture treatment in PD patients who received western medicine. In the short-term acupuncture treatment study, 20 patients received acupuncture therapy twice a week in acupoints DU 20, GB 20, LI 11, LI 10, LI 4, GB 31, ST 32, GB 34 and GB 38 along with western medicine for 18 weeks, and 20 controlled patients received western medicine only. In the long-term acupuncture treatment, 13 patients received acupuncture treatment twice a week for 36 weeks. The outcome parameters include Unified Parkinson's disease rating scale (UPDRS), Beck Anxiety Inventory (BAI), Beck Depression Inventory-Version 2 (BDI-II), and WHO quality of life (WHOQOL). In the short-term clinical trial, a higher percentage of patients in the acupuncture group had score improvement in UPDRS total scores (55% vs. 15%, p = 0.019), sub-score of mind, behavior and mood (85% vs. 25%, p < 0.001), activity of daily living (65% vs. 15%, p = 0.003), mobility (40% vs. 15%, p = 0.155) and complication of treatment (75% vs. 15%, p < 0.001), BDI-II score (85% vs. 35%, p = 0.003), and WHOQOL score (65% vs. 15%, p = 0.003) when compared to control group at the end of the 18 weeks' follow up. After 36 weeks of long-term acupuncture treatment, the mean UPDRS total scores and sub-score of mentation, behavior and mood, sub-score of complications of therapy and BDI-II score decreased significantly when compared to the pretreatment baseline. In conclusion, acupuncture treatment had integrated effects in reducing symptoms and signs of mind, behavior, mood, complications of therapy and depression in PD patients who received Western medicine.
    Keywords: Parkinson's Disease; Acupuncture; Integrative Therapy; QOL