Introduction of Dr. Ching-Mao Chang (Update on 2025/01/04)

Introduction of Dr. Ching-Mao Chang (NYCU) [簡介] 國立陽明交通大學醫學院傳統醫藥研究所-張清貿老師簡介 Ching-Mao Chang, M.D., Ph.D.  (張清貿, C.M. Chang)

Director, Division of Integrative Medicine Center for Traditional Medicine, Taipei Veterans General Hospital No.201, Sec. 2, Shipai Rd., Beitou District, Taipei City, Taiwan 11217, R.O.C TEL: +886-2-28757453 #304 E-Mail: tcmcmc@gmail.com Blog: http://tcmcmc.blogspot.tw/ ------------------------------------------------------ Dr.Ching-Mao Chang's personal introduction  Autoimmune Disease and Dry Eye Syndrome Objective Measurements Lab (AIDDES Lab) Director, Division of Integrative Medicine, Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei City, Taiwan https://www.vghtpe.gov.tw/Docpersnr.action?tno=DOC4331B Assistant professor of Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan https://tmi.nycu.edu.tw/en/full-time-teachers-2/ching-mao-chang/ ------------------------------------------------------ ***張清貿醫師只有FB官方粉專跟這個LINE官方帳號，沒有其他的群組，請認明正確帳號。 _____________________________________________________________________________

Evidence-Based Traditional Chinese Medicine for Sjögren Syndrome

EBM in TCM for Sjögren Syndrome/Sicca syndrome

BIOGRAPHY

Dr. Chang is a Director/Attending Physician (M.D.) in the Division of Integrative Medicine, Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, and an Assistant Professor in the Faculty of Medicine, National Yang Ming Chiao Tung University (Taipei). Dr. Chang was awarded his Ph.D. from the Graduate Institute of Clinical Medical Sciences (GICM), Chang Gung University, Taoyuan, Taiwan. His Ph.D. study, The Efficacy of Chinese Herbal Formula on Sjögren's syndrome and its Mechanism of Anti-oxidative and Immune Modulatory Effects, reflects his ongoing fascination with the ability of TCM treatment to not only relieve but also modify the debilitating symptoms associated with Sjögren's syndrome, including gastrointestinal discomfort, poor appetite, xerostomia, and aphthous ulcer.

Dr. Chang’s innovative research extends beyond herbal medicine to integrated TCM approaches, such as acupuncture and herbal formulations. He has led groundbreaking clinical trials, including the application of TBDESJS (Chun-Yu-Ching-Hua-Yin, CYCHY), a threefold-concentrated herbal decoction that demonstrated significant improvements in tear secretion, reduced artificial tear usage, and enhanced sleep quality in patients with Sjögren's syndrome and dry eye syndrome. Furthermore, Dr. Chang initiated the ACUDES (Acupuncture for Dry Eye Syndrome and Sjögren's Syndrome) clinical trial, which explored the effects of precise acupuncture at GB20 (Fengchi) and BL2 (Zanzhu) points. The results showed substantial increases in tear secretion and remarkable symptom relief, highlighting the potential of acupuncture in treating chronic dry eye conditions.

Since graduating with his Ph.D., Dr. Chang has received numerous accolades recognizing his outstanding contributions to education and research, including the "Best Teacher Award," "Traditional Chinese Medicine Excellent Academic Research Award," and "Distinguished Clinical Teaching Physician Award" from institutions such as Taipei Veterans General Hospital, the Taipei Chinese Medical Association, National Yang Ming Chiao Tung University, and the National Union of Chinese Medical Doctors’ Association.

RESEARCH INTERESTS

Dr. Chang specializes in traditional Chinese medicine and rheumatology. His main research interests involve TCM clinical trials, Sjögren’s syndrome, systemic lupus erythematosus, systemic sclerosis, and bioinformatics studies. As a key developer of the novel Chinese herbal medicine SS-1 (a triple combination of Chinese herbal preparations consisting of extracts of Gan-Lu-Yin, Sang-Ju-Yin, and Xuefu-Zhuyu-Decoction), he has applied SS-1 in the clinic with very successful outcomes in patients with Sjögren's syndrome.

Building on his work with SS-1, TBDESJS (CYCHY), and the ACUDES acupuncture therapy, Dr. Chang has demonstrated a dedication to integrating TCM into modern medical research to provide holistic and scientifically sound treatments. He is particularly keen on being involved in research collaborations that include biotechnology, bioinformatics, biopharmaceutics, and innovations in integrative medicine.

Education:

1. Ph.D., Graduate Institute of Clinical Medicine, Chang Gung University, Taoyuan, Taiwan
2. M.D., School of Chinese Medicine, China Medical University, Taichung, Taiwan

Current Employment:

1. Director, Division of Integrative Medicine, Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
2. Assistant professor, Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
3. Assistant Professor, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

Employment Record:

1. Visiting Research Scholar, Center for Complementary and Integrative Medicine, Division of Rheumatology, Tufts Medical Center, Boston, US
2. Attending physician (M.D.), Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
3. TCM Chief Resident Physician, Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
4. TCM Resident Doctor, Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
5. Internship, Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan

Academic Record:

1. Associate Editor, Session of Rheumatology, Frontiers in Medicine, Switzerland
2. Member of Adaptation Committee, Taiwan Herbal Pharmacopeia 4th Edition, Department of Chinese Medicine and Pharmacy, Ministry of Health and Welfare, Taipei, Taiwan

Association:

1. National Union of Chinese Medical Doctors’Association, R.O.C
2. Taipei Chinese Medical Association
3. Taiwain Clinical Chinese Medicine Association
4. Chinese Medical Association of Acupuncture
5. Taiwan Society of Chinese Medicine Otolaryngology
6. Taiwan Rheumatology Association
7. The Chinese Society of Immunology(CSI)
8. Taiwan Society for Integration of Chinese and Western Medicine

Awards:

1. "Best Teacher Award 2021", Taipei Veterans General Hospital, 2021
2. "Traditional Chinese Medicine excellent Academic Research Award": Chinese herbal medicine SS-1 inhibits T cell activation and ameliorates TH responses in Sjögren’s syndrome, Taipei Chinese Medical Association, Taipei, Taiwan, 2021
3. "Traditional Chinese Medicine excellent Academic Research Award": Stability of a Lupus Nephritis Case after One Year of Integrated Therapy, Taipei Chinese Medical Association, Taipei, Taiwan, 2021
4. "Traditional Chinese Medicine excellent Academic Research Award": TCM Insomnia OSCE Video education, Taipei, Taiwan, 2021
5. "Distinguished Clinical Teaching Physician Award", Taipei Veterans General Hospital", Veterans Affairs Council (VAC), R.O.C, 2020
6. "Traditional Chinese Medicine excellent Academic Research Award", National Union of Chinese Medical Doctors’Association, R.O.C, 2020
7. "Traditional Chinese Medicine excellent Academic Research Award": Integrated therapy decreases the mortality of patients with polymyositis and dermatomyositis: A Taiwan-wide population-based retrospective study , Taipei Chinese Medical Association, Taipei, Taiwan, 2020
8. "Traditional Chinese Medicine excellent Academic Research Award": Laser Acupuncture for Carpal Tunnel Syndrome: A Single-Blinded Controlled Study, Taipei Chinese Medical Association, Taipei, Taiwan, 2020
9. "Excellent Teacher Award", 108-2 , PBL, Faculty of Medicine, National Yang-Ming University, 2020
10. "Excellent Teacher Award", 108-1 , PBL, Faculty of Medicine, National Yang-Ming University, 2020
11. "Traditional Chinese Medicine excellent Academic Research Award", National Union of Chinese Medical Doctors’Association, R.O.C, 2019
12. "Traditional Chinese Medicine excellent Academic Research Award": Integrated Therapy Improve Urinary Total Protein in Patients with Lupus Nephritis: A Case Report , Taipei Chinese Medical Association, Taipei, Taiwan, 2019
13. "Best Teacher Award 2020", Taipei Veterans General Hospital, 2020
14. "Excellent Teacher Award", 107-2 , PBL, Faculty of Medicine, National Yang-Ming University, 2019
15. "Excellent Teacher Award", 107-2 , PBL, Faculty of Medicine, National Yang-Ming University, 2019
16. "Best Physician Award", Taipei Veterans General Hospital", Veterans Affairs Council (VAC), R.O.C, 2018
17. "Traditional Chinese Medicine excellent Academic Research Award", National Union of Chinese Medical Doctors’Association, R.O.C, 2018
18. "Excellent Teacher Award", 106-2 , PBL, Faculty of Medicine, National Yang-Ming University, 2018
19. "Best Teacher Award 2018", Taipei Veterans General Hospital, 2018
20. "Traditional Chinese Medicine excellent Academic Research Award", National Union of Chinese Medical Doctors’Association, R.O.C, 2017
21. "Best Teacher Award 2017", Taipei Veterans General Hospital", 2017
22. "Traditional Chinese Medicine excellent Academic Research Award": Integrative Therapy Decreases the Risk of Lupus Nephritis in Patients with Systemic Lupus Erythematosus: A Population-Based Retrospective Cohort Study , Taipei Chinese Medical Association, Taipei, Taiwan, 2017
23. "Traditional Chinese Medicine excellent Academic Research Award": The Core Pattern Analysis on Chinese Herbal Medicine for Sjögren's syndrome: A Nationwide Population-Based Study , Taipei Chinese Medical Association, Taipei, Taiwan, 2016
24. "Traditional Chinese Medicine excellent Academic Research Award": How to understand the TCM Zheng, Taipei Chinese Medical Association, Taipei, Taiwan, 2016
25. "Distinguished Clinical Teaching Physician Award", Taipei Veterans General Hospital", Veterans Affairs Council (VAC), R.O.C, 2015
26. "Best Intern Award", China Medical University Hospital, Taichung, Taiwan, 2010
27. "Oral Presentation Excellence Award" in Research Conference, China Medical University, Taichung, Taiwan, 2010

Research  Interest:

1. Traditional Chinese Medicine in Allergy, Immunology, Rheumatology：中醫過敏風濕免疫學 
2. TCM Clinical trial：中醫藥臨床試驗 
3. Sjögren syndrome：修格蘭氏症、乾燥症
4. Systemic Lupus Erythematosus：紅斑性狼瘡 
5. Systemic Sclerosis：硬皮症
6. Bioinformatics：生物資訊

Clinical expertise:

1. Sjögren syndrome/Sicca Syndrome (Dry Eye, Dry month)：修格蘭氏症 /乾燥症 (口乾、眼乾)
2. Systemic Lupus Erythematosus：紅斑性狼瘡 
3. Systemic Sclerosis：硬皮症
4. Rheumatoid arthritis：類風濕性關節炎
5. Ankylosing spondylitis：僵直性脊椎炎
6. Autoimmune Rheumatic Diseases：自體免疫風濕疾病
7. Dry Eye Syndrome/Keratoconjunctivitis：乾眼症
8. Allergic Rhinitis： 過敏性鼻炎 
9. Insomnia/ Sleep disorder：失眠/睡眠障礙 
10. Anxiety/Depressive disorder：焦慮、憂鬱症 
11. Chronic Fatigue Syndrome： 慢性疲勞症候群 
12. Sleep Obstructive Disease/Obstructive Sleep Apnea (OSA)： 睡眠呼吸中止症 
13. Gastrointestinal disorder：腸胃道疾病 
14. Gastroesophageal reflux disease (GERD)：胃食道逆流
15. Migraine：偏頭痛
16. Irritable Bowel Syndrome：大腸激躁症 
17. Dizziness/Vertigo Disorder： 頭昏/眩暈 
18. Hepatitis B/C： B/C型肝炎 
19. Myofascial pain syndrome：筋肌膜炎症候群 
20. Osteoarthritis：退化性關節炎 
21. Acupuncture & Moxibustion： 針灸

Ph.D. Thesis:

 (2012-2017, Ph.D. Candidate since 2014/06/13, Ph.D. since 2017/07)

<中藥臨床試驗暨轉譯醫學研究>

• 中文：中藥複方治療修格蘭氏症之療效評估及其抗氧化與免疫調控機轉之研究
• 英文：The Efficacy of Chinese Herbal Formula on Sjögren's syndrome and its Mechanism of Anti-oxidative and Immune Modulatory Effects

Contact Information:

• Ching-Mao Chang, M.D., Ph.D. Candidate (張清貿, C.M. Chang)
• Center for Traditional Medicine, Taipei Veterans General Hospital
• No.201, Sec. 2, Shipai Rd., Beitou District, Taipei City, Taiwan 11217, R.O.C
• TEL: +886-2-28757453 #304
• E-Mail: tcmcmc@gmail.com
• Blog: http://tcmcmc.blogspot.tw/

----------------------------

NYCU 「中醫自體免疫暨乾眼症客觀量測實驗室」捐款計畫

Q120120 中醫自體免疫暨乾眼症客觀量測實驗室

https://donate.nycu.edu.tw/contents/project_ct?page=1&p_id=63

中醫自體免疫暨乾眼症客觀量測實驗室 (Traditional Chinese medicine Autoimmune Disease and Dry Eye Syndrome Objective Measurements Lab，AIDDES Lab)致力於結合中醫理論與現代科技，進行前瞻性的研究，探索自體免疫風溼疾病與乾眼症患者的病理機轉及中醫輔助治療。AIDDES實驗室聚焦於透過客觀量測訊號，如中醫體質、舌診、脈診、虹膜、甲褶及心律變異等，加上DNA、RNA、蛋白質體學、口腔微生物菌相等生物醫學指標，深入探討客觀與生物醫學指標與自體免疫疾病的相關性，並進行跨領域的研究，以期建立更科學且精確的診斷與治療方法。

此外，我們也積極運用人工智慧及深度學習技術，對中醫體質、舌診、脈診資料進行自動化分析，並將其應用於處方的個人化設計。並希望可以通過基因序列、蛋白質體學、口腔微生物菌相…等研究，揭示自體免疫風溼疾病及乾眼症在分子生物學層面的機轉，並探索其中草藥及針灸等臨床介入方法的療效與潛力。我們的研究不僅有助於推動自體免疫疾病的精準醫療，還旨在構建真實世界的大數據研究，為未來的臨床決策提供有力支持。

因此，我們發起此捐款計畫，希望借助各界的支持，為患者帶來更好的醫療選擇，並推動中西醫結合。我們研究最終目標是幫助廣大的自體免疫疾病及乾眼症患者，減輕患者口眼乾燥症狀，提升生活品質，促進健康。

本專案將用於下列用途：

1.先進儀器設備的購置與升級：採購各類先進的研究儀器來提升實驗的精確度與效率，這包括心律變異係數分析儀、舌診及脈診儀、虹膜儀、甲褶鏡、基因定序……等設備，用於收集與分析患者的生理訊號與分子數據。

2.人工智慧與深度學習系統的開發與應用：我們計劃進行於人工智慧技術的開發，尤其是在中醫體質、舌診及脈診數據的自動化分析和中醫處方分析系統，目的是提高中醫診斷的準確性與中醫處方的精確度。我們將構建深度學習模型，並持續優化其性能，以應對複雜的臨床數據。

3.基因及多體學研究：為了探索自體免疫風溼疾病及乾眼症的病理機轉，我們將進行基因體、蛋白質體學、口腔微生物菌相等多體學研究，這不僅包括基因序列分析，還涉及RNA定序、蛋白質功能表現及口腔微生物菌相之變化。我們的目標是找出影響疾病發展的關鍵因子，從而發現新的治療靶點。

4.中草藥及針灸的臨床介入研究：我們將以嚴謹的臨床試驗設計，對中草藥及針刺療法在自體免疫疾病及乾眼症中進行療效分析與科學性驗證，中醫要擊針灸的大規模隨機對照試驗，可嚴謹評估中醫療法的有效性與安全性。

5.大數據研究平台的建立：為了促進長期數據的收集與分析，我們將建立自體免疫疾病暨乾眼症的的大數據研究平台，利用真實世界的數據進行病患狀況追蹤、療效評估及疾病預測。這將有助於我們對疾病進行全面的、長期的觀察，並為未來的臨床應用提供科學證據。

6.科研人才的培育與發展：我們希望藉由此捐款計畫，培育優良的碩博士學生與研究員培育，提供學術課程、研討會與研究資源，鼓勵他們投入中醫藥、針灸進行自體免疫疾病與乾眼症相關領域研究。我們也將與國際頂尖學術機構合作，促進國際交流與技術提升。

7.國際學術交流與成果發表：我們將積極參與國際學術會議，發表研究成果，並與全球學者進行交流。我們的目標是讓AIDDES實驗室的研究成果獲得全球認可，並推廣至更廣泛的臨床應用情境，造福更多的患者。

本捐款計畫將為AIDDES實驗室的研究提供強大的支持，幫助我們未來的科學技術提昇、臨床試驗、多體學整分析及大數據研究上持續發展，並加速推動中西醫結合研究的進展。我們衷心感謝您的支持與關注，期待與您共同創造更美好的醫療未來。