張清貿醫師自體免疫疾病之中西醫整合醫學研究 - 修格蘭氏症/乾燥症(Sjögren Syndrome)之中西醫實證探討: 7月 2016

剛剛看PAPER看到最新一期的Nature Reviews Disease Primers期刊在講Sjögren syndrome 修格蘭氏症，就下載來看看，發現大部分的觀念我都看過了，然後看到Table 2列出正在進行診斷與治療修格蘭氏症的研究(Ongoing diagnostic and therapeutic studies in primary SjS)，本來只是匆匆一瞥，突然看到一個熟悉的字眼「SS1」，就回頭仔細看，還真的是張恒鴻教授、魏耀揮教授以及潘台龍教授等指導教授帶者我一起進行的Sjögren syndrome 修格蘭氏症SS-1中醫藥臨床試驗 (NCT02110446 Chinese herbal formula SS1)，已於2016年04月21日臨床收案完畢，目前正在進行統計分析，感謝這麼多乾燥症患者願意支持，不離不棄。

雖然臨床試驗被引用好像也沒什麼用途，但看到辛苦做的研究被引用就覺得是一種很奇妙的感覺，未來希望所作的研究也能多多被引用。

最近在進行結果分析，發現初步有顯著療效，希望未來在博士論文口試及投稿也可以順利。

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http://www.nature.com/articles/nrdp201647

http://www.ncbi.nlm.nih.gov/pubmed/27383445

Nat Rev Dis Primers. 2016 Jul 7;2:16047. doi: 10.1038/nrdp.2016.47.
Sjögren syndrome.


Brito-Zerón P1,2,3, Baldini C4, Bootsma H5, Bowman SJ6, Jonsson R7,8, Mariette X9,10, Sivils K11, Theander E12, Tzioufas A13, Ramos-Casals M2,3,14.

Abstract
Sjögren syndrome (SjS) is a systemic autoimmune disease that primarily affects the exocrine glands (mainly the salivary and lacrimal glands) and results in the severe dryness of mucosal surfaces, principally in the mouth and eyes. This disease predominantly affects middle-aged women, but can also be observed in children, men and the elderly. The clinical presentation of SjS is heterogeneous and can vary from sicca symptoms to systemic disease (characterized by peri-epithelial lymphocytic infiltration of the affected tissue or the deposition of the immune complex) and lymphoma. The mechanism underlying the development of SjS is the destruction of the epithelium of the exocrine glands, as a consequence of abnormal B cell and T cell responses to the autoantigens Ro/SSA and La/SSB, among others. Diagnostic criteria for SjS include the detection of autoantibodies in patient serum and histological analysis of biopsied salivary gland tissue. Therapeutic approaches for SjS include both topical and systemic treatments to manage the sicca and systemic symptoms of disease. SjS is a serious disease with excess mortality, mainly related to the systemic involvement of disease and the development of lymphomas in some patients. Knowledge of SjS has progressed substantially, but this disease is still characterized by sicca symptoms, the systemic involvement of disease, lymphocytic infiltration to exocrine glands, the presence of anti-Ro/SSA and anti-La/SSB autoantibodies and the increased risk of lymphoma in patients with SjS.